Details

Autor(en) / Beteiligte

• Antonio, Leen
• Wu, Frederick C W
• Moors, Hannes
• Matheï, Cathy
• Huhtaniemi, Ilpo T
• Rastrelli, Giulia
• Dejaeger, Marian
• O'Neill, Terence W
• Pye, Stephen R
• Forti, Gianni
• Maggi, Mario
• Casanueva, Felipe F
• Slowikowska-Hilczer, Jolanta
• Punab, Margus
• Tournoy, Jos
• Vanderschueren, Dirk

Titel

Erectile dysfunction predicts mortality in middle-aged and older men independent of their sex steroid status

Ist Teil von

• Age and ageing, 2022-04, Vol.51 (4)

Ort / Verlag

England: Oxford Publishing Limited (England)

Erscheinungsjahr

2022

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• erectile dysfunction is associated with mortality, whereas the association between low testosterone (T) and higher mortality remains controversial. Sexual dysfunction and low T often coexist, but the relative importance of sexual symptoms versus low T in predicting mortality is not known. We studied the interrelationships between sex steroids and sexual symptoms with all-cause mortality in a large prospective cohort of European men. survival status was assessed in 1,788 community-dwelling men, aged 40-79, who participated in the European Male Ageing Study (EMAS). Sexual symptoms were evaluated via a validated questionnaire (EMAS-SFQ). Sex steroids were measured by mass spectrometry. Cox proportional hazard models were used to study the association between hormones, sexual symptoms and mortality. about 420 (25.3%) men died during a mean follow-up of 12.6 ± 3.1 years. Total T levels were similar in both groups, but free T was lower in those who died. Men with three sexual symptoms (erectile dysfunction, reduced morning erections and lower libido) had a higher mortality risk compared with men with none of these symptoms (adjusted hazard ratio (HR) and 95% confidence intervals: 1.75 (1.28-2.40, P = 0.001)). Particularly, erectile dysfunction and poor morning erections, but not lower libido, were associated with increased mortality (HR 1.40 (1.13-1.74, P = 0.002), 1.28 (1.04-1.59, P = 0.023) and 1.12 (0.90-1.39, P = 0.312), respectively). Further adjusting for total T, free T or oestradiol did not influence the observed risk. sexual symptoms, in particular erectile dysfunction, predict all-cause mortality independently of sex steroids and can be an early warning sign of a poor health status.