Details

Autor(en) / Beteiligte

• Tang, B Q
• Cai, Z H
• Lin, D N
• Wang, Z X
• Liang, X J
• Fan, Z P
• Huang, F
• Liu, Q F
• Zhou, H S

Titel

Prognostic significance of IKZF1 gene deletions in patients with B-cell acute lymphoblastic leukemia

Ist Teil von

• Zhōnghuá xuèyèxué zázhì, 2022-03, Vol.43 (3), p.235-240

Ort / Verlag

China

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• This study aimed to investigate the prognostic significance of IKZF1 gene deletion in patients with acute B lymphoblastic leukemia (B-ALL) . The clinical data of 142 patients with B-ALL diagnosed in Nanfang Hospital between March 2016 and September 2019 were analyzed. IKZF1 deletion was found in 36.0% of the 142 patients with B-ALL, whereas exon 4-7 deletion was found in 44.0% . White blood cell counts were higher in patients with the IKZF1 deletion (52.0% and 28.3% , =0.005) ; these patients also experienced worse effects of mid-term induction therapy (40.0% and 70.7% , <0.001) and had a higher proportion of Philadelphia chromosome-positive (52.0% and 21.7% , respectively, <0.001) . Univariate analysis revealed that the 3-year overall survival rate (OS) and event-free survival rate (EFS) in the IKZF1 deletion group were significantly lower than the IKZF1 wild-type group [ (37.1±7.3) % (54.7±5.4) % , (51.8±7.9) % (73.9±4.7) % ; =0.025, 0.013, respectively]. Multivariable analysis showed that harboring IKZF1 d