Details

Autor(en) / Beteiligte

• Nalio Ramos, Rodrigo
• Missolo-Koussou, Yoann
• Gerber-Ferder, Yohan
• Bromley, Christian P.
• Bugatti, Mattia
• Núñez, Nicolas Gonzalo
• Tosello Boari, Jimena
• Richer, Wilfrid
• Menger, Laurie
• Denizeau, Jordan
• Sedlik, Christine
• Caudana, Pamela
• Kotsias, Fiorella
• Niborski, Leticia L.
• Viel, Sophie
• Bohec, Mylène
• Lameiras, Sonia
• Baulande, Sylvain
• Lesage, Laëtitia
• Nicolas, André
• Meseure, Didier
• Vincent-Salomon, Anne
• Reyal, Fabien
• Dutertre, Charles-Antoine
• Ginhoux, Florent
• Vimeux, Lene
• Donnadieu, Emmanuel
• Buttard, Bénédicte
• Galon, Jérôme
• Zelenay, Santiago
• Vermi, William
• Guermonprez, Pierre
• Piaggio, Eliane
• Helft, Julie

Titel

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

Ist Teil von

• Cell, 2022-03, Vol.185 (7), p.1189-1207.e25

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Quelle

ScienceDirect

Beschreibungen/Notizen

• Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2+ macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8+ T cells. FOLR2+ macrophages efficiently prime effector CD8+ T cells ex vivo. The density of FOLR2+ macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies. [Display omitted] •FOLR2+ macrophages are tissue-resident cells found in healthy and malignant breasts•FOLR2+ macrophages reside in a perivascular niche in the tumor stroma•FOLR2+ macrophages interact with tumor-infiltrating CD8+ T cells•FOLR2+ macrophages positively correlate with T cell infiltration and better prognosis A subset of macrophages marked by FOLR2 that interact with tumor-infiltrating CD8+ T cells are associated with favorable prognosis.