Details

Autor(en) / Beteiligte

• Mu, Bing
• Xia, Shiwei
• Wu, Linna
• Li, Jingya
• Li, Zhongxian
• Wang, Zechao
• Wu, Junliang

Titel

Radical Esterification of Unactivated Alkenes Using Formate as Carbonyl Source

Ist Teil von

• Journal of organic chemistry, 2022-04, Vol.87 (7), p.4918-4925

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• In recent years, methyl formate has received considerable attention as an ideal and green C1 building block to synthesize carboxylic esters. However, examples of a one-step route to esters with one-carbon elongation using methyl formate as a source of methoxycarbonyl radical are still rare. Herein, we present peroxide-induced radical carbonylation of N-(2-methylallyl)­benzamides with methyl formate as the precursor of methoxycarbonyl radical and RuCl3 as catalyst, affording a series of biologically valuable 4-[(methoxycarbonyl)­methyl]-3,4-dihydroisoquinolinones with good tolerance and insensitivity to moisture in one pot under simple and mild conditions.