Details

Autor(en) / Beteiligte

• Aoshima, Chihiro
• Fujimoto, Shinichiro
• Kudo, Ayako
• Kawaguchi, Yuko O.
• Takamura, Kazuhisa
• Matsue, Yuya
• Kato, Takao
• Kawamura, Yoshifumi
• Kimura, Satoshi
• Kamo, Yuki
• Nozaki, Yui O.
• Takahashi, Daigo
• Tomizawa, Nobuo
• Hiki, Makoto
• Kasai, Takatoshi
• Nojiri, Shuko
• Miyauchi, Hideyuki
• Hirano, Ken-ichi
• Shimada, Kazunori
• Murakami, Koji
• Minamino, Tohru

Titel

Clinical significance of 123I-BMIPP washout rate in patients with uncertain chronic heart failure

Ist Teil von

• European journal of nuclear medicine and molecular imaging, 2022-07, Vol.49 (9), p.3129-3139

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background Recently, triglyceride deposit cardiomyovasculopathy (TGCV) with defective intracellular lipolysis was found to be a disease that causes heart failure. As a diagnostic criterion for TGCV, an Iodaine-123-β-methyl iodophenyl-pentadecanoic acid washout rate (BMIPP WOR) of < 10% is used, but its clinical significance in patients with heart failure remains to be clarified. Methods In 62 hospitalized patients with chronic heart failure, 123 I-BMIPP myocardial single-photon emission computed tomography (SPECT) was performed predischarge state. The prevalence of TGCV was investigated. Subsequently, follow-up was conducted for ≥ 90 days (mean: 724.6 ± 392.7 days), and the association between the BMIPP WOR and cardiac events was examined, establishing all-cause mortality and admission due to heart failure as endpoints. Results Of the 62 patients, the WOR was < 10% in 41 (66.1%). Of these, 26 (41.9%) were diagnosed with definite TGCV. Furthermore, cardiac events were noted in 12 patients (19.4%). Analysis with Cox proportional hazards models showed that the BMIPP WOR < 4.5% was a significant event-predicting factor [HR 4.29, 95% CI: 1.20–16.87; p  = 0.0245]. On a Kaplan–Meier curve, the WOR was 4.5%; there was a significant difference in the incidence of events ( p  = 0.0298). Conclusion In the predischarge state of heart failure, 123 I-BMIPP myocardial SPECT was performed. In approximately 40% of the patients, a diagnosis of TGCV was made. The results suggested that the BMIPP WOR is useful for predicting the prognosis of chronic heart failure patients regardless of TGCV.