Details

Autor(en) / Beteiligte

• Zhai, De-Hua
• Yan, Bing-Xia
• Li, Zhan-Cai
• Lin, Zhu
• Li, Qiang
• Wang, Yan-Lan
• Zheng, Hong-Xing
• Zhao, Chang-Qiu

Titel

The stereoselective conversion of epimerized alkoxyl phosphine-borane to P,C, axial -stereogenic tertiary phosphine via cleavage of P-O bond

Ist Teil von

• Organic & biomolecular chemistry, 2022-03, Vol.20 (13), p.2615-2620

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• The P-O bond of epimerized alkoxyl phosphine-borane was cleaved by naphthalene-lithium, to form two diastereomers of P-anions in a ratio of 86 : 14, which was then converted to secondary phosphine-borane acidification, and to tertiary phosphines with alkyl halides with enhanced 96 : 4 dr. The isolated tertiary phosphine containing hydroxyl (in >99 : 1 dr) was converted to multi-stereogenic tertiary phosphines -alkylation with alkylene dihalides.