Details

Autor(en) / Beteiligte

• Marutani, Noriko
• Akamine, Shoshin
• Kanayama, Daisuke
• Gotoh, Shiho
• Yanagida, Kanta
• Maruyama, Riki
• Mori, Kohji
• Miyamoto, Tesshin
• Adachi, Hiroyoshi
• Sakagami, Yukako
• Yoshiyama, Kenji
• Hotta, Maki
• Nagase, Aki
• Kozawa, Junji
• Maeda, Norikazu
• Otsuki, Michio
• Matsuoka, Takaaki
• Iwahashi, Hiromi
• Shimomura, Iichiro
• Murayama, Norihito
• Watanabe, Hiroshi
• Ikeda, Manabu
• Mizuta, Ichiro
• Kudo, Takashi

Titel

Plasma NfL is associated with mild cognitive decline in patients with diabetes

Ist Teil von

• Psychogeriatrics, 2022-05, Vol.22 (3), p.353-359

Ort / Verlag

Melbourne: John Wiley & Sons Australia, Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Patients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated whether plasma NfL levels were associated with cognitive decline in patients with type 2 diabetes. Method This study included 183 patients with type 2 diabetes who visited Osaka University Hospital. All participants were tested for cognitive function using the Mini‐Mental State Examination (MMSE) and the Rivermead Behavioural Memory Test (RBMT). NfL levels were analysed in the plasma and the relationship between NfL and cognitive function was examined. Results Lower RBMT‐standardized profile scores (SPS) or MMSE scores correlated with higher plasma NfL levels (one‐way analysis of variance: MMSE, P = 0.0237; RBMT‐SPS, P = 0.0001). Furthermore, plasma NfL levels (β = −0.34, P = 0.0005) and age (β = −0.19, P = 0.016) were significantly associated with the RBMT score after multivariable regression adjustment. Conclusions Plasma NfL levels were correlated with mild cognitive decline which is detected by the RBMT but not the MMSE in patients with type 2 diabetes. This suggests that plasma NfL levels may provide a valuable clinical tool for identifying mild cognitive decline in patients with diabetes.