Details

Autor(en) / Beteiligte

• Betancor, Diana
• Sastre, Joaquin

Titel

Reply to “Should measurements of exhaled nitric oxide before and after specific inhalation test with occupational allergens be performed?”

Ist Teil von

• The journal of allergy and clinical immunology in practice (Cambridge, MA), 2022-03, Vol.10 (3), p.888-889

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Whereas Merget and van Kampen1 and Engel et al2 defined a positive SIC by a 20% decrease in FEV1, we used a 15% or 2.5-fold increase in PC20 methacholine challenge, as suggested in a European Respiratory Society consensus statement.5 In our 216-patient study, we calculated the sensitivity and specificity of FeNO according to the criteria of van Kampen (20% FEV1 fall during SIC). [...]FeNO may aid in interpreting SIC, but the predictive diagnostic capacity of FeNO in OA remains controversial. P = .1 Negative SIC: 48.5 ± 63.7 Positive SIC: 39.9 ± 27.9 Negative SIC: 40.7 ± 124.2 Positive SIC: 34.9 ± 43.8 FeNO after SIC (mean ± SD) 50.5 ± 36.9 58.6 ± 209.0 Negative SIC: 47.54 ± 41.8 Positive SIC: 55.4 ± 32.6 Negative SIC: 46.8 ± 148.7 Positive SIC: 80.9 ± 289.9 FeNO change (ppb) (mean ± SD) 9.6 ± 30.7 6.2 ± 24.3 Negative SIC: 8.7 ± 20.1 Positive SIC: 17.9 ± 24.6 Negative SIC: 4.6 ± 17.8 Positive SIC: 11.7 ± 29.9 FeNO % change (mean ± SD) 12.6 ± 48.7 3.8 ± 41.8 Negative SIC: 5.6 ± 55.5 Positive SIC: 19.6 ± 36.9 Negative SIC: 0.5 ± 42.5 Positive SIC: 8.7 ± 41.7 Area under the curve for absolute FeNO change, value (95% confidence interval) 0.58 (0.42-0.74) Sensitivity: 70.8% Specificity: 57.1% 0.53 (0.43-0.63) Sensitivity: 27.3% Specificity: 87.0% Area under the curve for relative FeNO change, value (95% confidence interval) 0.58 (0.41-0.74) Sensitivity: 63.6% Specificity: 57.1% 0.54 (0.44-0.64) Sensitivity: 69.1% Specificity: 12.0% Table I FeNO values in study occupational asthma patients according to diagnostic criteria used by van Kampen et al1,2