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Reply to “Should measurements of exhaled nitric oxide before and after specific inhalation test with occupational allergens be performed?”
Ist Teil von
The journal of allergy and clinical immunology in practice (Cambridge, MA), 2022-03, Vol.10 (3), p.888-889
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2022
Quelle
MEDLINE
Beschreibungen/Notizen
Whereas Merget and van Kampen1 and Engel et al2 defined a positive SIC by a 20% decrease in FEV1, we used a 15% or 2.5-fold increase in PC20 methacholine challenge, as suggested in a European Respiratory Society consensus statement.5 In our 216-patient study, we calculated the sensitivity and specificity of FeNO according to the criteria of van Kampen (20% FEV1 fall during SIC). [...]FeNO may aid in interpreting SIC, but the predictive diagnostic capacity of FeNO in OA remains controversial. P = .1 Negative SIC: 48.5 ± 63.7 Positive SIC: 39.9 ± 27.9 Negative SIC: 40.7 ± 124.2 Positive SIC: 34.9 ± 43.8 FeNO after SIC (mean ± SD) 50.5 ± 36.9 58.6 ± 209.0 Negative SIC: 47.54 ± 41.8 Positive SIC: 55.4 ± 32.6 Negative SIC: 46.8 ± 148.7 Positive SIC: 80.9 ± 289.9 FeNO change (ppb) (mean ± SD) 9.6 ± 30.7 6.2 ± 24.3 Negative SIC: 8.7 ± 20.1 Positive SIC: 17.9 ± 24.6 Negative SIC: 4.6 ± 17.8 Positive SIC: 11.7 ± 29.9 FeNO % change (mean ± SD) 12.6 ± 48.7 3.8 ± 41.8 Negative SIC: 5.6 ± 55.5 Positive SIC: 19.6 ± 36.9 Negative SIC: 0.5 ± 42.5 Positive SIC: 8.7 ± 41.7 Area under the curve for absolute FeNO change, value (95% confidence interval) 0.58 (0.42-0.74) Sensitivity: 70.8% Specificity: 57.1% 0.53 (0.43-0.63) Sensitivity: 27.3% Specificity: 87.0% Area under the curve for relative FeNO change, value (95% confidence interval) 0.58 (0.41-0.74) Sensitivity: 63.6% Specificity: 57.1% 0.54 (0.44-0.64) Sensitivity: 69.1% Specificity: 12.0% Table I FeNO values in study occupational asthma patients according to diagnostic criteria used by van Kampen et al1,2