Details

Autor(en) / Beteiligte

• Tual-Chalot, Simon
• Stellos, Konstantinos

Titel

Chrono-pharmacology-based antiplatelet therapy for acute myocardial infarction

Ist Teil von

• European heart journal, 2022-06, Vol.43 (24), p.2335-2337

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2022

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Graphical Abstract Graphical Abstract Chrono-pharmacology-based antiplatelet therapy. Mammalian Rev-erbα expression in platelets shows a circadian rhythm and reaches its highest expression at 9 a.m., a time corresponding to the occurrence of major adverse cardiovascular events. Increased Rev-erbα expression leads to an increased platelet aggregation, while both genetic deletion and pharmacological inhibition of Rev-erbα decreased multiple aspects of mouse and human platelet activation. Rev-erbα platelet-specific knockout mice (Plt.-specific Rev-erbα KO mice) have prolonged bleeding time and reduced extent of thrombosis in the ferric chloride-induced thrombosis mouse model and reduced infarct size after experimental acute myocardial infarction.