Molecular neurobiology, 2022-05, Vol.59 (5), p.2946-2961
2022
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- Autor(en) / Beteiligte
- Titel
- Activation of the GPX4/TLR4 Signaling Pathway Participates in the Alleviation of Selenium Yeast on Deltamethrin-Provoked Cerebrum Injury in Quails
- Ist Teil von
- Molecular neurobiology, 2022-05, Vol.59 (5), p.2946-2961
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2022
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- Deltamethrin (DLM) is a member of pyrethroid pesticide widely applied for agriculture and aquaculture, and its residue in the environment seriously threatens the bio-safety. The cerebrum might be vulnerable to pesticide-triggered oxidative stress. However, there is no specific antidote for treating DLM-triggered cerebral injury. Selenium (Se) is an essential trace element functionally forming selenoprotein glutathione peroxidase (GPX) in antioxidant defense. Se yeast (SY) is a common and effective organic form of Se supplement with high selenomethionine content. Accordingly, this study focused on investigating the therapeutic potential of SY on DLM-induced cerebral injury in quails after chronically exposing to DLM and exploring the underlying mechanisms. Quails were treated with/without SY (0.4 mg kg −1 SY added in standard diet) in the presence/absence of DLM (45 mg kg −1 body weight intragastrically) for 12 weeks. The results showed SY supplementation ameliorated DLM-induced cerebral toxicity. Concretely, SY elevated the content of Se and increased GPX4 level in DLM-treated quail cerebrum. Furthermore, SY enhanced antioxidant defense system by upregulating nuclear factor-erythroid-2-related factor 2 (Nrf2) associated members. Inversely, SY diminished the changes of apoptosis- and inflammation-associated proteins and genes including toll-like receptor 4 (TLR4). Collectively, our results suggest that dietary SY protects against DLM-induced cerebral toxicity in quails via positively regulating the GPX4/TLR4 signaling pathway. GPX4 may be a potential therapeutic target for insecticide-induced biotoxicity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0893-7648eISSN: 1559-1182DOI: 10.1007/s12035-022-02744-3Titel-ID: cdi_proquest_miscellaneous_2636154939
- Format
- –
- Schlagworte
- Animals, Antioxidants, Antioxidants - metabolism, Apoptosis, Biomedical and Life Sciences, Biomedicine, Body weight, Cell Biology, Cerebrum, Cerebrum - metabolism, Deltamethrin, Glutathione peroxidase, Homeostasis, Laboratory animals, Neurobiology, Neurology, Neurosciences, Nitriles, Organisms, Oxidative stress, Pesticides, Proteins, Pyrethrins, Pyrethroids, Quail - metabolism, Saccharomyces cerevisiae - metabolism, Selenium, Selenium - pharmacology, Selenomethionine, Signal Transduction, Therapeutic targets, TLR4 protein, Toll-Like Receptor 4 - metabolism, Toll-like receptors, Toxicity, Trace elements (nutrients), Tumor necrosis factor-TNF