Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Toward recovery in schizophrenia: Current concepts, findings, and future research directions
Ist Teil von
Psychiatry and clinical neurosciences, 2022-07, Vol.76 (7), p.282-291
Ort / Verlag
Melbourne: John Wiley & Sons Australia, Ltd
Erscheinungsjahr
2022
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Schizophrenia was initially defined as “dementia praecox” by E. Kraepelin, which implies progressive deterioration. However, recent studies have revealed that early effective intervention may lead to social and functional recovery in schizophrenia. In this review, we provide an overview of current concepts in schizophrenia and pathophysiological hypotheses. In addition, we present recent findings from clinical and basic research on schizophrenia. Recent neuroimaging and neurophysiological studies have consistently revealed specific biological differences in the structure and function of the brain in those with schizophrenia. From a basic research perspective, to determine the essential pathophysiology underlying schizophrenia, it is crucial that findings from all lines of inquiry—induced pluripotent stem cell (iPSC)‐derived neural cells from patients, murine models expressing genetic mutations identified in patients, and patient clinical data—be integrated to contextualize the analysis results. However, the findings remain insufficient to serve as a diagnostic tool or a biomarker for predicting schizophrenia‐related outcomes. Collaborations to conduct clinical research based on the patients' and their families' values are just beginning, and further development is expected.