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The biological applicability of nanomaterials has been limited due to cytotoxicity. Studies have described the effects of nanomaterials on different tissues and cell types, but their actions on immune cells are less elucidated. This study describes unprecedented in vitro and in vivo antioxidant activities of cadmium selenide magic-sized quantum dots (CdSe MSQDs) with implications on rheumatoid arthritis. While the generation of ROS induced by nanomaterials is linked to cytotoxicity, we found that CdSe MSQDs reduced ROS production by neutrophils and macrophages following opsonized-zymosan stimuli, and we did not find cytotoxic effects. Interestingly, inherent antioxidant properties of CdSe MSQDs were confirmed through DPPH, FRAP, and ORAC assays. Furthermore, CdSe MSQDs reduced ROS levels generated by infiltrating leukocytes into joints in experimental model of rheumatoid arthritis. Briefly, we describe a novel application of CdSe MSQDs in modulating the inflammatory response in experimental rheumatoid arthritis through an unexpected antioxidant activity.
CdXSe magic-sized quantum dots (MSQDs) inactivate reactive oxygen species (ROS) generated by neutrophils and macrophages following zymosan-opsonized stimulus. The scavenging activity of CdXSe MSQDs also has implications in joint inflammation, since their effects are reproduced in model of zymosan-induced arthritis, an experimental model of rheumatoid arthritis. [Display omitted]
•CdSe-MSQDs control the ROS levels generated by neutrophils and macrophages.•Cell viability is not modified by CdSe-MSQDs.•Reduction of ROS levels is associated to inherent antioxidant activity of CdSe-MSQDs.•CdSe-MSQDs reduce ROS generated by leukocytes in the joint in experimental arthritis.