Details

Autor(en) / Beteiligte

• Li, Jia-Qin
• Chen, Xiao-Hui
• Cui, Hai-Lei

Titel

Modification of Pyrrolo[2,1‑a]isoquinolines and Pyrrolo[1,2‑a]quinolines with Ammonium Acetate and Dimethyl Sulfoxide via Methylthiomethylation

Ist Teil von

• Journal of organic chemistry, 2022-03, Vol.87 (5), p.2421-2434

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An efficient methylthiomethylation of pyrroloisoquinolines and pyrroloquinolines has been reached by the use of ammonium acetate and dimethyl sulfoxide. Methylthiomethylated heterocycles can be obtained in moderate to good yields in most cases, while trace amounts to good yields of methylene-bridged products can be observed. Choice of DMSO activator and its amount have a great influence on the chemoselectivity of this process. It is worth noting that this process can also be scalable. Another feature of this process is that the product can be transformed to sulfone and sulfoxide easily.