Details

Autor(en) / Beteiligte

• Stoevesandt, Johanna
• Keita, Dyamilatou Ulrike
• Goebeler, Matthias

Titel

Disease‐related burden and long‐term outcome in orofacial granulomatosis: observations from a large single‐centre cohort

Ist Teil von

• Clinical and experimental dermatology, 2022-06, Vol.47 (6), p.1169-1173

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Summary There is a lack of standardized treatment recommendations for orofacial granulomatosis, a chronic inflammatory condition aetiologically related to Crohn disease. To assess clinical baseline parameters and treatment strategies, we retrospectively analysed 61 consecutive cases from our institutional database. Disease‐related functional/psychological impairment and long‐term outcomes were descriptively evaluated using a standardized self‐reporting questionnaire. The median age of patients was 45 (7–77) years. Oral steroids were given in 41.0% of cases, but only produced short‐term disease control, while response to steroid‐sparing agents was inconsistent. Only a minority of patients reported relevant disease‐related functional impairment in eating (21.7%) or speaking (4.3%), but the majority perceived psychological distress due to the cosmetic aspects of the disease (69.6%), comments from others (65.2%) and/or general anxiety/insecurity (73.9%). Regardless of the initial treatment, long‐term outcomes after 71 months (range 7–304 months) were beneficial, with most patients being in complete remission (52.2%) or reporting only mild residual swelling (43.5%). Orofacial granulomatosis (OFG) may manifest throughout a lifetime and is not restricted to children and young adults. Although associated functional impairment is rare, OFG is associated with considerable psychological distress. Long‐term outcomes after a median of 71 months are beneficial regardless of the initial treatment.