Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
The use of denosumab to treat giant cell tumors of bone (GCT) and other giant cell‐containing bone tumors has become more common. While the clinicopathologic features of denosumab‐treated giant cell tumors of bone have been well‐illustrated, descriptions of other denosumab‐treated bone tumors are very limited. Surgical pathology files of two institutions and consultation files from two authors were searched for denosumab‐treated aneurysmal bone cysts and denosumab‐treated osteoblastomas. Clinicopathologic features were reviewed and analyzed. We identified four patients with denosumab‐treated bone tumors other than GCT from our surgical pathology and consultation files, including two aneurysmal bone cysts and two osteoblastomas. All were treated with denosumab for 0.5‐7.0 (median 4.5) months. Radiologically, denosumab‐treated tumors showed decreased size with increased ossification and mineralization on CT and heterogeneous intermediate to hypointense signal on MRI. Histologically, denosumab‐treated aneurysmal bone cyst contained thin, elongated, curvilinear, and anastomosing strands of bone with empty lacunae, while denosumab‐treated osteoblastoma showed circumscribed nodules of woven bone lined by small osteoblasts. Denosumab‐treated aneurysmal bone cyst and osteoblastoma showed treatment‐related morphologic changes that can mimic other bone neoplasms. Their recognition requires correlation with the clinical history of denosumab use and radiologic findings.