Details

Autor(en) / Beteiligte

• Qi, Xiangyu
• Wang, Gang
• Wang, Peng
• Pei, Yao
• Zhang, Caiyun
• Yan, Miao
• Wei, Pengfei
• Tian, Geng
• Zhang, Guilong

Titel

Transferrin Protein Corona-Modified CuGd Core–Shell Nanoplatform for Tumor-Targeting Photothermal and Chemodynamic Synergistic Therapies

Ist Teil von

• ACS applied materials & interfaces, 2022-02, Vol.14 (6), p.7659-7670

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Herein, we developed a novel transferrin protein corona (Tpc)-modified CuGd nanoplatform (Tpc-CuGd) for tumor-targeting photothermal (PT) and chemodynamic synergistic therapy. In addition, Tpc-CuGd had an ultrahigh PT conversion efficiency (∼55.6%) and excellent PT stability. By the calculation, the Fenton-catalytic activity of Tpc-CuGd was approximately 13.6 times that of classical ultrasmall iron oxide, endowing strong chemodynamic therapy ability in the tumor. Upon internalization of Tpc-CuGd nanoparticles (NPs), an abundance of Cu­(II) was released from Tpc-CuGd and then was quickly reduced to high Fenton-catalytic activity of Cu­(I) by elemental copper and cellular GSH. Next, the generated Cu­(I) quickly catalyzed H2O2 into highly toxic •OH, causing mitochondria damage and inducing cancer cell death. In addition, the systemic delivery of Tpc-CuGd significantly inhibited tumor growth and showed a very low toxicity. Notably, the PT effect of Tpc-CuGd NPs not only promoted their tumor inhibitory capability but also significantly restricted the continued growth of the tumor after the discontinuation of the treatment. In addition, Tpc-CuGd significantly strengthened the T1-weighted signal of tumors and realized accurate cancer diagnosis. Therefore, this nanoplatform could be a great promising candidate for PT and chemodynamic synergistic theranostics.