Details

Autor(en) / Beteiligte

• Zhang, Stanley
• Wang, Ke
• Zhu, Xue
• Cherepanoff, Svetlana
• Conway, R. Max
• Madigan, Michele C.
• Zhu, Ling
• Murray, Michael
• Zhou, Fanfan

Titel

The unfolded protein response and the biology of uveal melanoma

Ist Teil von

• Biochimie, 2022-06, Vol.197, p.9-18

Ort / Verlag

France: Elsevier B.V

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Uveal melanoma (UM) is a highly metastatic ocular cancer that arises from the melanocytes of the uveal tract (the choroid, ciliary body and iris). Despite a growing understanding of UM biology, effective systemic treatments are currently lacking and the cancer has an extremely poor prognosis. Therefore, identifying novel agents that act by new tumorigenic mechanisms in UM is essential to address this unmet clinical need. Endoplasmic reticulum (ER) stress occurs when misfolded proteins accumulate in the organelle, and the unfolded protein response (UPR) is the cellular mechanism that is activated so that cells may adapt to the situation. Dysregulated UPR signalling has been detected in UM tumors and has been associated with an increase in immune evasion and metastatic activity. A number of established and novel oncology drugs act in part by modulating ER stress and the UPR. The induction of protein-folding stress and the UPR could be a novel approach for the development of new therapeutics in UM. Further studies are now warranted to understand the mechanisms and consequences of UPR signalling in UM. [Display omitted] •Uveal melanoma (UM) is a highly metastatic ocular cancer without systemic treatment.•Sustained unfolded protein response (UPR) activation has been demonstrated in UM.•Many aspects of UM biology are related to the persistent UPR activation.•Understanding how UPR signalling contributes to UM biology.•It enables the development of effective therapeutics in treating UM.