Details

Autor(en) / Beteiligte

• Spengler, Jessica R
• Kainulainen, Markus H
• Welch, Stephen R
• Coleman-McCray, JoAnn D
• Harmon, Jessica R
• Condrey, Jillian A
• Scholte, Florine E M
• Nichol, Stuart T
• Montgomery, Joel M
• Albariño, César G
• Spiropoulou, Christina F

Titel

Lassa Virus Replicon Particle Vaccine Protects Strain 13/N Guinea Pigs Against Challenge With Geographically and Genetically Diverse Viral Strains

Ist Teil von

• The Journal of infectious diseases, 2022-11, Vol.226 (9), p.1545-1550

Ort / Verlag

United States: Infectious Diseases Society of America

Erscheinungsjahr

2022

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Lassa virus (LASV) causes mild to severe hemorrhagic fever disease in humans. Strain 13/N guinea pigs are highly susceptible to infection with LASV strain Josiah (clade IV), providing a critical model system for therapeutics and vaccine development. To develop additional models of disease, we detail the clinical course in guinea pigs infected with 5 geographically and genetically diverse LASV strains. Two of the developed models (LASV clades II and III) were then used to evaluate efficacy of a virus replicon particle vaccine against heterologous LASV challenge, demonstrating complete protection against clinical disease after a single vaccination dose.