Details

Autor(en) / Beteiligte

• Son, Da-Hye
• Lee, Hye Sun
• Lee, Yong-Jae
• Lee, Jun-Hyuk
• Han, Jee-Hye

Titel

Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome

Ist Teil von

• Nutrition, metabolism, and cardiovascular diseases, 2022-03, Vol.32 (3), p.596-604

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Insulin resistance is related closely to metabolic syndrome (MetS). The homeostasis model assessment of insulin resistance (HOMA-IR) is the most commonly used insulin resistance index, but the triglyceride-glucose (TyG) index has been suggested as a reliable alternative insulin resistance index. This study aims to compare the predictive powers of TyG index and HOMA-IR for the prevalence and incidence of MetS in a large, community-based, prospective cohort over 12 years of follow-up. Data from 9730 adults with or without MetS at baseline, 6091 adults without MetS who were followed as part of the Korean Genome and Epidemiology Study were analyzed. Receiver-operating-characteristic (ROC) curves and time-dependent ROC curves were performed to compare the areas under the ROC curve (AUROC) of the TyG index and HOMA-IR for predicting the prevalence and incidence of MetS. The optimal cut-off points were calculated. Cox proportional hazard spline curves were used to verify dose-response relationship between TyG index/HOMA-IR and incident MetS. TyG index showed higher predictive power for prevalent MetS than HOMA-IR (0.837 vs. 0.680, p < 0.001). The AUROC for incident MetS of TyG index and HOMA-IR was 0.654 (0.644–0.664) and 0.556 (0.531–0.581), respectively (p < 0.001). Cut-off points of TyG index and HOMA-IR for predicting the prevalence of MetS were 8.718 and 1.8 and for predicting incident MetS were 8.518 and 1.5, respectively. Both TyG index and HOMA-IR had a linear relationship with incident MetS. TyG index is superior to HOMA-IR for predicting MetS. [Display omitted] •HOMA-IR and TyG index are commonly used insulin resistance index.•TyG index is superior to HOMA-IR for predicting the prevalence of metabolic syndrome.•The predictive power for incident metabolic syndrome is significant only for the TyG index, not HOMA-IR.•TyG index is a useful surrogate marker for the management and prevention of metabolic syndrome.