Details

Autor(en) / Beteiligte

• Wratil, Paul R
• Stern, Marcel
• Priller, Alina
• Willmann, Annika
• Almanzar, Giovanni
• Vogel, Emanuel
• Feuerherd, Martin
• Cheng, Cho-Chin
• Yazici, Sarah
• Christa, Catharina
• Jeske, Samuel
• Lupoli, Gaia
• Vogt, Tim
• Albanese, Manuel
• Mejías-Pérez, Ernesto
• Bauernfried, Stefan
• Graf, Natalia
• Mijocevic, Hrvoje
• Vu, Martin
• Tinnefeld, Kathrin
• Wettengel, Jochen
• Hoffmann, Dieter
• Muenchhoff, Maximilian
• Daechert, Christopher
• Mairhofer, Helga
• Krebs, Stefan
• Fingerle, Volker
• Graf, Alexander
• Steininger, Philipp
• Blum, Helmut
• Hornung, Veit
• Liebl, Bernhard
• Überla, Klaus
• Prelog, Martina
• Knolle, Percy
• Keppler, Oliver T
• Protzer, Ulrike

Titel

Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern

Ist Teil von

• Nature medicine, 2022-03, Vol.28 (3), p.496-503

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Infection-neutralizing antibody responses after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 vaccination are an essential component of antiviral immunity. Antibody-mediated protection is challenged by the emergence of SARS-CoV-2 variants of concern (VoCs) with immune escape properties, such as omicron (B.1.1.529), which is rapidly spreading worldwide. Here we report neutralizing antibody dynamics in a longitudinal cohort of coronavirus disease 2019 convalescent and infection-naive individuals vaccinated with mRNA BNT162b2 by quantifying SARS-CoV-2 spike protein antibodies and determining their avidity and neutralization capacity in serum. Using live-virus neutralization assays, we show that a superior infection-neutralizing capacity against all VoCs, including omicron, developed after either two vaccinations in convalescents or a third vaccination or breakthrough infection of twice-vaccinated, naive individuals. These three consecutive spike antigen exposures resulted in an increasing neutralization capacity per anti-spike antibody unit and were paralleled by stepwise increases in antibody avidity. We conclude that an infection-plus-vaccination-induced hybrid immunity or a triple immunization can induce high-quality antibodies with superior neutralization capacity against VoCs, including omicron.