Details

Autor(en) / Beteiligte

• Chen, Junjie
• Lu, Cui'e
• Wang, Xiaodong
• Wang, Lin
• Chen, Jia
• Ji, Fuhai

Titel

LncRNA NONRATT009773.2 promotes bone cancer pain progression through the miR‐708‐5p/CXCL13 axis

Ist Teil von

• The European journal of neuroscience, 2022-02, Vol.55 (3), p.661-674

Ort / Verlag

France: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

EBSCOhost Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• Bone cancer pain (BCP) is the most frequently observed chronic cancer pain, and its development remains largely unexplored. Dysregulation of non‐coding RNAs greatly contributes to the pathogenesis of BCP. In the present study, we found a new long noncoding RNA (lncRNA), NONRATT009773.2, and investigated its role in the spinal cord of BCP rats. Our results showed that NONRATT009773.2 was significantly up‐regulated in BCP model rats, whereas depletion of NONRATT009773.2 attenuated BCP. In contrast, overexpression of NONRATT009773.2 triggered pain‐like symptoms in normal animals. Moreover, NONRATT009773.2 functioned as a microRNA (miRNA) sponge to absorb miR‐708‐5p and up‐regulated miRNA downstream target CXCL13, which plays fundamental roles in the initiation and maintenance of neuroinflammation and hyperalgesia. Collectively, our current findings indicated that NONRATT009773.2 could be employed as a new therapeutic target for BCP. Dysregulation of non‐coding RNAs greatly contributes to the pathogenesis of bone cancer pain (BCP). We found a differentially expressed lncRNA, NONRATT009773.2, and investigated its role in the spinal cord of BCP rats. NONRATT009773.2 functioned as a miRNA sponge to absorb miR‐708‐5p and up‐regulated miRNA downstream target CXCL13, which plays fundamental roles in the initiation and maintenance of neuroinflammation and hyperalgesia.