Details

Autor(en) / Beteiligte

• Davis‐Wilson, Hope C.
• Thoma, Louise M.
• Johnston, Christopher D.
• Young, Emma
• Evans‐Pickett, Alyssa
• Spang, Jeffrey T.
• Blackburn, J. Troy
• Hackney, Anthony C.
• Pietrosimone, Brian

Titel

Fewer daily steps are associated with greater cartilage oligomeric matrix protein response to loading post‐ACL reconstruction

Ist Teil von

• Journal of orthopaedic research, 2022-10, Vol.40 (10), p.2248-2257

Ort / Verlag

United States

Erscheinungsjahr

2022

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Aberrant joint loading contributes to the development of posttraumatic knee osteoarthritis (PTOA) following anterior cruciate ligament reconstruction (ACLR); yet little is known about the association between joint loading due to daily walking and cartilage health post‐ACLR. Accelerometer‐based measures of daily steps and cadence (i.e., rate of steps/min) provide information regarding daily walking in a real‐world setting. The purpose of this study was to determine the association between changes in serum cartilage oligomeric matrix protein (COMP; %∆COMP), a mechanosensitive biomarker that is associated with osteoarthritis progression, following a standardized walking protocol and daily walking in individuals with ACLR and uninjured controls. Daily walking was assessed over 7 days using an accelerometer worn on the right hip in 31 individuals with ACLR and 21 controls and quantified as mean steps/day and time spent in ≥100 steps/min. Serum COMP was measured before and following a 3000‐step walking protocol at a preferred speed. %∆COMP was calculated as a change in COMP relative to the prewalking value. Linear regressions were used to examine associations between daily walking and %∆COMP after adjusting for preferred speed. Fewer daily steps (ΔR2 = 0.18, p = 0.02) and fewer minutes spent in ≥100 steps/min (ΔR2 = 0.16, p = 0.03) were associated with greater %∆COMP following walking in individuals with ACLR; no statistically significant associations existed in controls (daily steps: ΔR2 = 0.03, p = 0.47; time ≥100 steps/min: ΔR2 < 0.01, p = 0.81). Clinical significance: Individuals with ACLR who engage in less daily walking undergo greater %ΔCOMP, which may represent greater cartilage degradation or turnover in response to walking.