Details

Autor(en) / Beteiligte

• Vandervelde, Christelle M.
• Vos, Robin
• Vanluyten, Cedric
• Fieuws, Steffen
• Verleden, Stijn E.
• Van Slambrouck, Jan
• De Leyn, Paul
• Coosemans, Willy
• Nafteux, Philippe
• Decaluwé, Herbert
• Van Veer, Hans
• Depypere, Lieven
• Dauwe, Dieter F.
• De Troy, Erwin
• Ingels, Catherine M.
• Neyrinck, Arne P.
• Jochmans, Ina
• Vanaudenaerde, Bart M.
• Godinas, Laurent
• Verleden, Geert M.
• Van Raemdonck, Dirk E.
• Ceulemans, Laurens J.

Titel

Impact of anastomosis time during lung transplantation on primary graft dysfunction

Ist Teil von

• American journal of transplantation, 2022-05, Vol.22 (5), p.1418-1429

Ort / Verlag

United States: Elsevier Limited

Erscheinungsjahr

2022

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Primary graft dysfunction (PGD) is a major obstacle after lung transplantation (LTx), associated with increased early morbidity and mortality. Studies in liver and kidney transplantation revealed prolonged anastomosis time (AT) as an independent risk factor for impaired short‐ and long‐term outcomes. We investigated if AT during LTx is a risk factor for PGD. In this retrospective single‐center cohort study, we included all first double lung transplantations between 2008 and 2016. The association of AT with any PGD grade 3 (PGD3) within the first 72 h post‐transplant was analyzed by univariable and multivariable logistic regression analysis. Data on AT and PGD was available for 427 patients of which 130 (30.2%) developed PGD3. AT was independently associated with the development of any PGD3 ≤72 h in uni‐ (odds ratio [OR] per 10 min 1.293, 95% confidence interval [CI 1.136–1.471], p < .0001) and multivariable (OR 1.205, 95% CI [1.022–1.421], p = .03) logistic regression analysis. There was no evidence that the relation between AT and PGD3 differed between lung recipients from donation after brain death versus donation after circulatory death donors. This study identified AT as an independent risk factor for the development of PGD3 post‐LTx. We suggest that the implantation time should be kept short and the lung cooled to decrease PGD‐related morbidity and mortality post‐LTx. Implantation time during lung transplantation is a risk factor for primary graft dysfunction.