Details

Autor(en) / Beteiligte

• Mutoh, Tomoyuki
• Nagai, Taichi
• Shirai, Tsuyoshi
• Okazaki, Soshi
• Sato, Hiroko
• Fujii, Hiroshi

Titel

Predictive factors for retention of golimumab over a median 4‐year duration in Japanese patients with rheumatoid arthritis in a real‐world setting: A retrospective study and literature review

Ist Teil von

• International journal of rheumatic diseases, 2022-03, Vol.25 (3), p.335-343

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Objectives To investigate 6‐year drug survival (median: 48.5 months) of golimumab and predictors for lack of efficacy leading to golimumab discontinuation in Japanese patients with rheumatoid arthritis (RA) in routine practice. Methods This retrospective single‐center study included 60 patients with RA treated with golimumab from November 2011 to August 2020. Patients were divided into 2 groups (retention, n = 28; withdrawal due to lack of efficacy, n = 24). The retention rate was assessed using the Kaplan‐Meier method, and variables associated with golimumab discontinuation were identified using the Cox proportional hazard model. Results The prevalence of concomitant methotrexate and no biologics use was significantly higher in the retention than in the withdrawal group. Overall drug survival of golimumab was 66.3%, 48.3%, and 24.5% at 12, 36, and 72 months, respectively. There were statistical differences in retention rates among groups stratified by initiation dose, methotrexate, and biologics use. Multivariate analysis revealed the factor associated with golimumab discontinuation as history of 1 (hazards ratio: 4.42, 95% CI: 1.35‐19.93, P = .012) and ≥2 biologics use (7.49, 1.97‐36.27, P = .003). Conclusions Prior exposure of increasing number of biologics was identified as the most important factor negatively affecting long‐term golimumab retention in Japanese patients with RA.