Details

Autor(en) / Beteiligte

• Haebe, Sarah
• Keay, William
• Alig, Stefan
• Mohr, Anne‐Wiebe
• Martin, Larissa K.
• Heide, Michael
• Secci, Ramona
• Krebs, Stefan
• Blum, Helmut
• Moosmann, Andreas
• Louissaint, Abner
• Weinstock, David M.
• Thoene, Silvia
• Bergwelt‐Baildon, Michael
• Ruland, Jürgen
• Bararia, Deepak
• Weigert, Oliver

Titel

The molecular ontogeny of follicular lymphoma: gene mutations succeeding the BCL2 translocation define common precursor cells

Ist Teil von

• British journal of haematology, 2022-03, Vol.196 (6), p.1381-1387

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2022

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Summary Relapsed follicular lymphoma (FL) can arise from common progenitor cells (CPCs). Conceptually, CPC‐defining mutations are somatic alterations shared by the initial and relapsed tumours, mostly B‐cell leukaemia/lymphoma 2 (BCL2)/immunoglobulin heavy locus (IGH) translocations and other recurrent gene mutations. Through complementary approaches for highly sensitive mutation detection, we do not find CPC‐defining mutations in highly purified BCL2/IGH‐negative haematopoietic progenitor cells in clinical remission samples from three patients with relapsed FL. Instead, we find cells harbouring the same BCL2/IGH translocation but lacking CREB binding protein (CREBBP), lysine methyltransferase 2D (KMT2D) and other recurrent gene mutations. Thus, (i) the BCL2/IGH translocation can precede CPC‐defining mutations in human FL, and (ii) BCL2/IGH‐translocated cells can persist in clinical remission.