Details

Autor(en) / Beteiligte

• Takahashi, Koji
• Sasaki, Daisuke
• Yamashita, Mina
• Sakaue, Tomoki
• Enomoto, Daijiro
• Morioka, Hiroe
• Uemura, Shigeki
• Okura, Takafumi
• Ikeda, Shuntaro
• Kono, Taizo
• Hiratsuka, Yoshiyasu
• Saijo, Akira
• Yamamura, Nobuhisa
• Kitazawa, Sohei
• Yamashita, Taro
• Ueda, Mitsuharu

Titel

Amyloid deposit corresponds to technetium-99m-pyrophosphate accumulation in abdominal fat of patients with transthyretin cardiac amyloidosis

Ist Teil von

• Journal of nuclear cardiology, 2022-12, Vol.29 (6), p.3126-3136

Ort / Verlag

Cham: Elsevier Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Radionuclide imaging using bone-avid tracers plays a critical role in diagnosing transthyretin cardiac amyloidosis (ATTR-CA), but technetium-99m-pyrophosphate (PYP) rarely allows the detection of extracardiac amyloid infiltration. We retrospectively investigated the frequency of PYP uptake in the subcutaneous abdominal fat of patients with ATTR-CA and its relevance to the results of fine-needle aspiration biopsy (FNAB) of this tissue. Chest-centered images of PYP scintigraphy were obtained 2 h after the intravenous injection of the tracer (20 mCi), and the frequency of PYP uptake in the subcutaneous abdominal fat was evaluated. Amyloid deposits of fat smears taken by subcutaneous abdominal fat FNAB were assessed by Congo red staining. Twenty-four patients with ATTR-CA were included. Ten (41.7%) patients showed some PYP uptake in the subcutaneous abdominal fat (positive PYP group), and 14 patients did not (negative PYP group). Amyloid deposits were detected by subcutaneous abdominal fat FNAB in 7/10 patients (70.0%) of the positive PYP group versus 0/14 patients (0%) of the negative PYP group, and the difference was significant. In patients with ATTR-CA, abnormal PYP uptake in the subcutaneous abdominal fat could reflect the regional amyloid deposition confirmed by FNAB of this tissue.