Details

Autor(en) / Beteiligte

• Lima, Thais C
• Magalhães, Lizandra G
• Paula, Lucas A de L
• Cunha, Wilson R
• Januário, Ana H
• Pauletti, Patricia M
• Bastos, Jairo K
• Dos Santos, Fransergio F
• Forim, Moacir R
• Laurentiz, Rosangela S
• Santos, Fernanda A
• Orenha, Renato P
• Parreira, Renato L T
• Fuzo, Carlos A
• Molina, Eduardo F
• Santos, Mario F C
• Silva, Márcio L A E

Titel

Evaluation of lignan-loaded poly(ε-caprolactone) nanoparticles: synthesis, characterization, in vivo and in silico schistosomicidal activity

Ist Teil von

• Natural product research, 2022-11, Vol.36 (22), p.1-5878

Ort / Verlag

England: Taylor & Francis Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Lignan dinitrohinokinin displays important biological activities, which led to the preparation of its poly-ε-caprolactone nanoparticles. Kinetics analysis revealed initially slow drug release followed by a prolonged, moderate release 6 h later due to DNHK diffusion through the polymeric matrix. Molecular dynamics simulations show that DNHK molecules that interact stronger with other DNHK molecules near the PCL/DNHK surface are more difficult to dissociate from the nanoparticle. The smaller diameter nanocapsules with negative surface charge conferred good colloidal stability. The formulations showed a size distribution with monodisperse systems formation. evaluation of schistosomicidal activity against showed that DNHK, when incorporated into nanoparticles, caused egg number reduction of 4.2% and 28.1% at 40 mg/kg and 94.2% and 84.4% at 400 mg/kg in the liver and the spleen, respectively. The PCL nanoparticles were stable in aqueous dispersion and could be optimized to be used as a promising lignan release agent.