Details

Autor(en) / Beteiligte

• Mondal, Atanu
• Satpathi, Bishnupada
• Ramasastry, S. S. V

Titel

Phosphine-Catalyzed Intramolecular Vinylogous Aldol Reaction of α‑Substituted Enones

Ist Teil von

• Organic letters, 2022-01, Vol.24 (1), p.256-261

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We demonstrate the first phosphine-catalyzed intramolecular vinylogous aldol reaction (IVAR) of α-substituted enones. This strategy provides access to various pentannulated (hetero)­arenes and dibenzocycloheptanones incorporated with two contiguous stereocenters, one of which is an all-carbon quaternary center. The scope of this work is further broadened through elaborations of the IVAR adducts to (i) benzannulated nine-membered carbocyclic systems, (ii) interesting classes of 1,3-dienes, 1,3,5-trienes, and 1-yn-3,5-dienes, and (iii) the analogs of echinolactone D and russujaponol F.