Details

Autor(en) / Beteiligte

• Lu, Sen
• Jiang, Hai‐yin
• Shi, Yu‐dan

Titel

Association between irritable bowel syndrome and Parkinson's disease: A systematic review and meta‐analysis

Ist Teil von

• Acta neurologica Scandinavica, 2022-04, Vol.145 (4), p.442-448

Ort / Verlag

Denmark: Hindawi Limited

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Growing evidence suggests that irritable bowel syndrome (IBS) and Parkinson's disease (PD) share similar pathological mechanisms and risk factors. Methods We performed a systematic review and meta‐analysis of the evidence for a relationship between IBS and PD. Risk estimates from individual studies were pooled using random‐effects models. Results Six articles involving 58,645 patients with PD were included in our meta‐analysis. The overall risk for PD in IBS patients was significantly higher than that in the general population (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.29–1.75; p < .001). Subgroup analysis revealed no significant differences in risk between men (OR = 1.47, 95% CI: 1.3–1.67; p < .001) and women (OR = 1.51, 95% CI: 1.29–1.75; p < .001); however, older (≥65 years) IBS patients (OR = 1.44, 95% CI: 1.3–1.59; p < .001) may be at higher risk for PD than younger (40–64 years) patients (OR = 1.32, 95% CI: 1.05–1.64; p = .017). Conclusion Overall, the PD risk was higher in IBS patients than others, indicating that the intestinal disorder may serve as a warning sign for PD.