Details

Autor(en) / Beteiligte

• Schade, L.
• Mesa, D.
• Faria, A.R.
• Santamaria, J.R.
• Xavier, C.A.
• Ribeiro, D.
• Hajar, F.N.
• Azevedo, V.F.

Titel

The gut microbiota profile in psoriasis: a Brazilian case‐control study

Ist Teil von

• Letters in applied microbiology, 2022-04, Vol.74 (4), p.498-504

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2022

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• The pathogenesis of psoriasis, an immune‐mediated chronic inflammatory skin disease, remains unclear. Studies have shown an association between psoriasis and intestinal inflammation; in this context, the influence of the gut microbiota on the immune response of psoriasis has become a focus of recent research. The present research evaluated the composition and diversity of the gut microbiota of 21 participants with psoriasis from a Brazilian referral dermatology service compared to 24 healthy controls. A stool sample was collected from each participant at the time of inclusion in the study, and the samples were analysed by sequencing the 16S rRNA gene. The recruitment of research participants involved matching between groups by sex, age, body mass index, comorbidities and smoking and the exclusion of several criteria that could potentially influence the gut microbiota and the interpretation of the data. There was an increase in the Dialister genus and Prevotella copri species in patients with psoriasis compared to the control group. A reduction in the Ruminococcus, Lachnospira and Blautia genera, as well as in the Akkermansia muciniphila species, was also verified in the psoriasis group compared to the control group. Furthermore, patients with psoriasis exhibited less gut microbiota diversity than controls. Significance and Impact of the Study: The data from this research will contribute to a better understanding of the role of the microbiota in the pathogenesis of psoriasis, contributing to the identification of biomarkers that will aid in early diagnosis and the choice or development of more personalized and effective treatments.