Details

Autor(en) / Beteiligte

• Festa, Stefano
• Zerboni, Giulia
• Derikx, Lauranne A A P
• Ribaldone, Davide Giuseppe
• Dragoni, Gabriele
• Buskens, Christianne
• van Dijkum, Els Nieveen
• Pugliese, Daniela
• Panzuto, Francesco
• Krela-Kaźmierczak, Iwona
• Mintz, Hilla Reiss
• Shitrit, Ariella Bar-Gil
• Chaparro, Marìa
• Gisbert, Javier P
• Kopylov, Uri
• Teich, Niels
• Vainer, Elez
• Nagtegaal, Iris
• Hoentjen, Frank
• Garcia, Maria Jose
• Filip, Rafal
• Foteinogiannopoulou, Kalliopi
• Koutroubakis, Ioannis E
• Argollo, Marjorie
• van Wanrooij, Roy L J
• Laja, Hendrik
• Lobaton, Triana
• Truyens, Marie
• Molnar, Tamas
• Savarino, Edoardo
• Aratari, Annalisa
• Papi, Claudio
• Goren, Idan

Titel

Gastroenteropancreatic Neuroendocrine Neoplasms in Patients with Inflammatory Bowel Disease: An ECCO CONFER Multicentre Case Series

Ist Teil von

• Journal of Crohn's and colitis, 2022-07, Vol.16 (6), p.940-945

Ort / Verlag

UK: Oxford University Press

Erscheinungsjahr

2022

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background Gastroenteropancreatic neuroendocrine neoplasms [GEP-NENs] have rarely been reported in association with inflammatory bowel diseases [IBDs]. Methods An ECCO COllaborative Network For Exceptionally Rare case reports project [ECCO-CONFER] collects cases of GEP-NENs diagnosed in patients with IBD. Results GEP-NEN was diagnosed in 100 IBD patients; 61% female, 55% Crohn’s disease, median age 48 years (interquartile range [IQR] 38-59]). The most common location was the appendix [39%] followed by the colon [22%]. Comprehensive IBD-related data were available for 50 individuals with a median follow-up of 30 months [IQR 11-70] following NEN diagnosis. Median duration of IBD at NEN diagnosis was 84 months [IQR 10-151], and in 18% of cases NEN and IBD were diagnosed concomitantly. At diagnosis, 20/50 were stage-I [T1N0M0], and 28/50 were graded G1 [ki67 ≤2%]. Incidental diagnosis of NEN and concomitantly IBD diagnosis were associated with an earlier NEN stage [p = 0.01 and p = 0.02, respectively]. Exposure to immunomodulatory or biologic therapy was not associated with advanced NEN stage or grade. Primary GEP-NEN were more frequently found in the segment affected by IBD [62% vs 38%]. At the last follow-up data, 47/50 patients were alive, and only two deaths were related to NEN. Conclusions In the largest case series to date, prognosis of patients with GEP-NEN and IBD seems favourable. Incidental NEN diagnosis correlates with an earlier NEN stage, and IBD-related therapies are probably independent of NEN stage and grade. The association of GEP-NEN location and the segment affected by IBD may suggest a possible role of inflammation in NEN tumorigenesis