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The veterinary journal (1997), 2022-01, Vol.279, p.105782-105782, Article 105782
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
2022
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
•This review describes 36 canine genodermatoses.•Details of the causative genetic variants are provided.•There is an overview of modern genetic methods in diagnostics and research.•Genetic analyses enable a precision medicine approach.•Genetic analyses are becoming increasingly relevant for veterinary clinicians.
Canine genodermatoses represent a broad spectrum of diseases with diverse phenotypes. Modern genetic technology including whole genome sequencing has expedited the identification of novel genes and greatly simplified the establishment of genetic diagnoses in such heterogeneous disorders. The precise genetic diagnosis of a heritable skin disorder is essential for the appropriate counselling of owners regarding the course of the disease, prognosis and implications for breeding. Understanding the underlying pathophysiology is a prerequisite to developing specific, targeted or individualized therapeutic approaches. This review aims to create a comprehensive overview of canine genodermatoses and their respective genetic aetiology known to date. Raising awareness of genodermatoses in dogs is important and this review may help clinicians to apply modern genetics in daily clinical practice, so that a precise diagnoses can be established in suspected genodermatoses.