Details

Autor(en) / Beteiligte

• Shen, Yingli
• Lifante, José
• Zabala‐Gutierrez, Irene
• Fuente‐Fernández, María
• Granado, Miriam
• Fernández, Nuria
• Rubio‐Retama, Jorge
• Jaque, Daniel
• Marin, Riccardo
• Ximendes, Erving
• Benayas, Antonio

Titel

Reliable and Remote Monitoring of Absolute Temperature during Liver Inflammation via Luminescence‐Lifetime‐Based Nanothermometry

Ist Teil von

• Advanced materials (Weinheim), 2022-02, Vol.34 (7), p.e2107764-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Temperature of tissues and organs is one of the first parameters affected by physiological and pathological processes, such as metabolic activity, acute trauma, or infection‐induced inflammation. Therefore, the onset and development of these processes can be detected by monitoring deviations from basal temperature. To accomplish this, minimally invasive, reliable, and accurate measurement of the absolute temperature of internal organs is required. Luminescence nanothermometry is the ideal technology for meeting these requirements. Although this technique has lately undergone remarkable developments, its reliability is being questioned due to spectral distortions caused by biological tissues. In this work, how the use of bright Ag2S nanoparticles featuring temperature‐dependent fluorescence lifetime enables reliable and accurate measurement of the absolute temperature of the liver in mice subjected to lipopolysaccharide‐induced inflammation is demonstrated. Beyond the remarkable thermal sensitivity (≈ 3% °C–1 around 37 °C) and thermal resolution obtained (smaller than 0.3 °C), the results included in this work set a blueprint for the development of new diagnostic procedures based on the use of intracorporeal temperature as a physiological indicator. Lifetime‐based infrared luminescent nanothermometers are shown to be minimally affected by the effects of biological tissues on the propagation of photons. Real‐time and reliable thermal monitoring of the liver of a mouse subjected to lipopolysaccharide‐induced inflammation is achieved through the use of bright Ag2S nanoparticles. Remarkable thermal sensitivity (3% °C–1 around 37 °C) and thermal resolution (smaller than 0.3 °C) are obtained.