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Longitudinal White Matter Damage Evolution in Parkinson's Disease
Movement disorders, 2022-02, Vol.37 (2), p.315-324
Scamarcia, Pietro Giuseppe
Agosta, Federica
Spinelli, Edoardo Gioele
Basaia, Silvia
Stojković, Tanja
Stankovic, Iva
Sarasso, Elisabetta
Canu, Elisa
Markovic, Vladana
Petrović, Igor
Stefanova, Elka
Pagani, Elisabetta
Kostic, Vladimir S.
Filippi, Massimo
2022
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Scamarcia, Pietro Giuseppe
Agosta, Federica
Spinelli, Edoardo Gioele
Basaia, Silvia
Stojković, Tanja
Stankovic, Iva
Sarasso, Elisabetta
Canu, Elisa
Markovic, Vladana
Petrović, Igor
Stefanova, Elka
Pagani, Elisabetta
Kostic, Vladimir S.
Filippi, Massimo
Titel
Longitudinal White Matter Damage Evolution in Parkinson's Disease
Ist Teil von
Movement disorders, 2022-02, Vol.37 (2), p.315-324
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2022
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
ABSTRACT Background White matter hyperintensities (WMHs) have a role in cognitive impairment in normal brain aging, while the effect on Parkinson's disease (PD) progression is still controversial. Objective To investigate the longitudinal evolution of micro‐ and macrostructural damage of cerebral white matter (WM) and its relationship with the clinical picture in PD. Methods A total of 154 PD patients underwent clinical, cognitive, and magnetic resonance imaging (MRI) assessment once a year for up to 4 years. Sixty healthy controls underwent the same protocol at baseline. WMHs were identified and total WMH volume was measured. WMHs were also used as exclusion masks to define normal‐appearing white matter (NAWM). Using tract‐based spatial statistics, diffusion tensor (DT) MRI metrics of whole‐brain WM and NAWM were obtained. Linear mixed‐effects models defined the longitudinal evolution and association between variables. WM alterations were tested as risk factors of disease progression using linear regression and Cox proportional hazards models. Results At baseline, PD patients showed alterations of all DT MRI measures compared to controls. Longitudinally, DT MRI measures did not vary significantly and no association with clinical variables was found. WMH volume changed over time and was associated with impairment in global cognition, executive functions, and language. Baseline WMH volume was a moderate risk factor for progression to mild cognitive impairment. Conclusions Our study suggests an association between WMHs and cognitive deterioration in PD, whereas WM microstructural damage is a negligible contributor to clinical deterioration. WMHs assessed by MRI can provide an important tool for monitoring the development of cognitive impairment in PD patients. © 2021 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.28864
Titel-ID: cdi_proquest_miscellaneous_2600822129
Format
–
Schlagworte
Aging
,
Cognitive ability
,
Cognitive Dysfunction - complications
,
Cognitive Dysfunction - etiology
,
Diffusion Tensor Imaging
,
Evolution
,
Humans
,
Longitudinal studies
,
longitudinal study
,
Magnetic resonance imaging
,
Magnetic Resonance Imaging - methods
,
Movement disorders
,
MRI
,
Neurodegenerative diseases
,
Neuroimaging
,
normal‐appearing white matter
,
Parkinson Disease - complications
,
Parkinson Disease - diagnostic imaging
,
Parkinson Disease - pathology
,
Parkinson's disease
,
Patients
,
Regression analysis
,
Risk factors
,
Substantia alba
,
White Matter - diagnostic imaging
,
White Matter - pathology
,
white matter hyperintensity
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