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Automated Whole-Liver MRI Segmentation to Assess Steatosis and Iron Quantification in Chronic Liver Disease
Radiology, 2022-02, Vol.302 (2), p.345-354
Martí-Aguado, David
Jiménez-Pastor, Ana
Alberich-Bayarri, Ángel
Rodríguez-Ortega, Alejandro
Alfaro-Cervello, Clara
Mestre-Alagarda, Claudia
Bauza, Mónica
Gallén-Peris, Ana
Valero-Pérez, Elena
Ballester, María Pilar
Gimeno-Torres, Marta
Pérez-Girbés, Alexandre
Benlloch, Salvador
Pérez-Rojas, Judith
Puglia, Víctor
Ferrández, Antonio
Aguilera, Victoria
Escudero-García, Desamparados
Serra, Miguel A
Martí-Bonmatí, Luis
2022
Details
Autor(en) / Beteiligte
Martí-Aguado, David
Jiménez-Pastor, Ana
Alberich-Bayarri, Ángel
Rodríguez-Ortega, Alejandro
Alfaro-Cervello, Clara
Mestre-Alagarda, Claudia
Bauza, Mónica
Gallén-Peris, Ana
Valero-Pérez, Elena
Ballester, María Pilar
Gimeno-Torres, Marta
Pérez-Girbés, Alexandre
Benlloch, Salvador
Pérez-Rojas, Judith
Puglia, Víctor
Ferrández, Antonio
Aguilera, Victoria
Escudero-García, Desamparados
Serra, Miguel A
Martí-Bonmatí, Luis
Titel
Automated Whole-Liver MRI Segmentation to Assess Steatosis and Iron Quantification in Chronic Liver Disease
Ist Teil von
Radiology, 2022-02, Vol.302 (2), p.345-354
Ort / Verlag
United States
Erscheinungsjahr
2022
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Background Standardized manual region of interest (ROI) sampling strategies for hepatic MRI steatosis and iron quantification are time consuming, with variable results. Purpose To evaluate the performance of automatic MRI whole-liver segmentation (WLS) for proton density fat fraction (PDFF) and iron estimation (transverse relaxometry [R2*]) versus manual ROI, with liver biopsy as the reference standard. Materials and Methods This prospective, cross-sectional, multicenter study recruited participants with chronic liver disease who underwent liver biopsy and chemical shift-encoded 3.0-T MRI between January 2017 and January 2021. Biopsy evaluation included histologic grading and digital pathology. MRI liver sampling strategies included manual ROI (two observers) and automatic whole-liver (deep learning algorithm) segmentation for PDFF- and R2*-derived measurements. Agreements between segmentation methods were measured using intraclass correlation coefficients (ICCs), and biases were evaluated using Bland-Altman analyses. Linear regression analyses were performed to determine the correlation between measurements and digital pathology. Results A total of 165 participants were included (mean age ± standard deviation, 55 years ± 12; 96 women; 101 of 165 participants [61%] with nonalcoholic fatty liver disease). Agreements between mean measurements were excellent, with ICCs of 0.98 for both PDFF and R2*. The median bias was 0.5% (interquartile range, -0.4% to 1.2%) for PDFF and 2.7 sec (interquartile range, 0.2-5.3 sec ) for R2* (P < .001 for both). Margins of error were lower for WLS than ROI-derived parameters (-0.03% for PDFF and -0.3 sec for R2*). ROI and WLS showed similar performance for steatosis (ROI AUC, 0.96; WLS AUC, 0.97; = .53) and iron overload (ROI AUC, 0.85; WLS AUC, 0.83; = .09). Correlations with digital pathology were high ( < .001) between the fat ratio and PDFF (ROI = 0.89; WLS = 0.90) and moderate ( < .001) between the iron ratio and R2* (ROI = 0.65; WLS = 0.64). Conclusion Proton density fat fraction and transverse relaxometry measurements derived from MRI automatic whole-liver segmentation (WLS) were accurate for steatosis and iron grading in chronic liver disease and correlated with digital pathology. Automated WLS estimations were higher, with a lower margin of error than manual region of interest estimations. © RSNA, 2021 See also the editorial by Moura Cunha and Fowler in this issue.
Sprache
Englisch
Identifikatoren
ISSN: 0033-8419
eISSN: 1527-1315
DOI: 10.1148/radiol.2021211027
Titel-ID: cdi_proquest_miscellaneous_2598080202
Format
–
Schlagworte
Biopsy
,
Chronic Disease
,
Cross-Sectional Studies
,
Deep Learning
,
Female
,
Humans
,
Iron Overload - diagnostic imaging
,
Iron Overload - pathology
,
Magnetic Resonance Imaging - methods
,
Male
,
Middle Aged
,
Non-alcoholic Fatty Liver Disease - diagnostic imaging
,
Non-alcoholic Fatty Liver Disease - pathology
,
Prospective Studies
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