Details

Autor(en) / Beteiligte

• Saravanan, S.
• Guleria, Neha
• Ranjitha, H.B.
• Sreenivasa, B.P.
• Hosamani, Madhusudan
• Prieto, Carlos
• Umapathi, V.
• Santosh, H.K.
• Behera, Subhasmita
• Dhanesh, V.V.
• Krishna, Gollapalli Sivarama
• Gopinath, Shreya
• Kolte, Atul
• Bayry, Jagadeesh
• Sanyal, Aniket
• Basagoudanavar, Suresh H.

Titel

Induction of antiviral and cell mediated immune responses significantly reduce viral load in an acute foot-and-mouth disease virus infection in cattle

Ist Teil von

• Genomics (San Diego, Calif.), 2021-11, Vol.113 (6), p.4254-4266

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Foot-and-mouth disease virus (FMDV) causes a severe infection in ruminant animals. Here we present an in-depth transcriptional analysis of soft-palate tissue from cattle experimentally infected with FMDV. The differentially expressed genes from two Indian cattle (Bos indicus) breeds (Malnad Gidda and Hallikar) and Holstein Friesian (HF) crossbred calves, highlighted the activation of metabolic processes, mitochondrial functions and significant enrichment of innate antiviral immune response pathways in the indigenous calves. The results of RT-qPCR based validation of 12 genes was in alignment with the transcriptome data. The indigenous calves showing lesser virus load, elicited early neutralizing antibodies and IFN-γ immune responses. This study revealed that induction of potent innate antiviral response and cell mediated immunity in indigenous cattle, especially Malnad Gidda, significantly restricted FMDV replication during acute infection. These data highlighting the molecular processes associated with host-pathogen interactions, could aid in the conception of novel strategies to prevent and control FMDV infection in cattle. •RNA-Seq transcriptome was compared in three breeds of cattle infected with FMDV.•The DEGs highlighted strong innate immunity in the indigenous Bos indicus calves.•Initiation of innate and cell mediated immunity contribute to a reduced viral load.