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Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity
Ist Teil von
Journal of natural medicines, 2022, Vol.76 (1), p.210-219
Ort / Verlag
Singapore: Springer Singapore
Erscheinungsjahr
2022
Quelle
MEDLINE
Beschreibungen/Notizen
Aplydactylonins A-C (
1
–
3
), three new sesquiterpenes, were isolated from the Vietnamese sea hare
Aplysia dactylomela
. Their structures and absolute configurations were elucidated based on spectroscopic analysis, X-ray crystallography, and density functional theory (DFT) calculations of NMR and ECD data. Compound
2
exhibited cytotoxicity against HepG2, DU145 and A549 cells with respective IC
50
values of 4.08 ± 0.63, 38.64 ± 1.04 and 12.33 ± 0.95 µM. In addition, HepG2 cells treated with 5 μM compound
2
for 48 h showed a significant increase in early apoptotic cells (
P
< 0.05) and increased caspase 3 activity (
P
< 0.01). Moreover, compound
2
induced sub-G1 phase arrest in HepG2 cells.