Details

Autor(en) / Beteiligte

• Dezaki, Katsuya
• Yada, Toshihiko

Titel

Status of ghrelin as an islet hormone and paracrine/autocrine regulator of insulin secretion

Ist Teil von

• Peptides (New York, N.Y. : 1980), 2022-02, Vol.148, p.170681-170681, Article 170681

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• •Ghrelin is expressed in the pancreatic islet cells as well as the stomach.•Pharmacological, immunological and genetic blockades of ghrelin in pancreatic islets augment glucose-induced insulin release.•Islet-derived ghrelin physiologically restricts insulin release in rodents via paracrine and autocrine pathways.•Ghrelin restricts insulin release via directly inhibiting β-cells and via promoting somatostatin secretion from δ-cells. Ghrelin is expressed in the pancreatic islet cells as well as the stomach. In the perfused pancreas and isolated islets, GHS-R antagonism, ghrelin immunoneutralization and ghrelin-knockout (Ghr-KO) all increase glucose-induced insulin release. Thus, pharmacological, immunological and genetic blockades of ghrelin in the pancreatic islets all markedly augment glucose-induced insulin release, showing that islet-derived ghrelin physiologically restricts insulin release in rodents. In this review, we focus on the current understanding of the following key questions: 1) from which islet cells ghrelin is released, 2) on which islet cells ghrelin acts, and 3) mechanisms by which the islet-derived ghrelin inhibits insulin secretion.