Details

Autor(en) / Beteiligte

• Castillo-Sánchez, Miguel
• Escurriola, Mireia Fàbregas
• Sanmartín, María Isabel Fernández
• Solntseva, Iryna
• Baquero, Daniel Bergè
• Arno, Alberto Goday

Titel

Cardiovascular disease and mortality in people with schizophrenia or antipsychotic treatment: A cohort study in primary care

Ist Teil von

• Psychiatry research, 2021-12, Vol.306, p.114233-114233, Article 114233

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• •People with schizophrenia have a greater cardiovascular risk.•Metabolic effect of antipsychotics, lifestyles and minor access to health services are keypoints.•Schizophrenia itself could be an independent cardiovascular risk factor.•In this study, schizophrenia was independently related with cardiovascular mortality.•Schizophrenia and antipsychotic drugs oblige to optimise cardiovascular prevention. People with schizophrenia (SZ) or under treatment with antipsychotic drugs (TAD) are considered to be at high risk of cardiovascular (CV) morbidity and mortality, but the reasons are not fully understood. In addition, no longitudinal studies in the setting of primary care in Spain have been performed. We aimed at analysing the incidence of cardiovascular disease (CVD) and CV mortality in the population with SZ and in the population without SZ but under TAD (NS-TAD). Retrospective cohort study in primary care in Spain, based on data from computerized medical records and mortality recorded in the National Statistics Institute. Three groups were generated: SZ, NS-TAD and control group, with a 4-year follow-up period (2008 to 2011). In an adjusted model, SZ was established as an independent risk factor for CV mortality although not with non-fatal CVD incidence. The NS-TAD group was an independent risk factor for mortality of any cause and CVD, but not CV mortality. Differences between SZ and NS-TAD support that SZ has an increased risk of CVD independently of TAD. Further studies to evaluate the origin and management are needed. The detection of CVD and the consequent secondary CV prevention in these high-risk populations should be prioritized. Herein, a greater interaction between primary care and mental health services is eagerly needed.