Details

Autor(en) / Beteiligte

• Almalki, Bassem
• Kane, Clare
• Cunningham, Kathleen
• D'Agostino, Carly
• Novak, Antonia
• Kapugi, Michelle
• Ladner, Daniela
• Schulte, Jamie

Titel

Evaluation of rejection, infection, and malignancy outcomes in elderly liver transplant recipients receiving a similar level of immunosuppression compared to a younger group

Ist Teil von

• Transplant immunology, 2021-12, Vol.69, p.101485-101485, Article 101485

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Elderly liver transplant (LTx) recipients at a lower risk of acute rejection compared to younger recipients due to immunosenescence. As such, they may benefit from reduced immunosuppression (IS) to minimize infectious and malignant complications. We aimed to evaluate outcomes in LTx recipients ≥60 years compared to a younger group of LTx recipients aged 18–59 years maintained on a similar level of IS. This was a single-center retrospective evaluation of adult LTx recipients from 2013 to 2018 who received methylprednisolone induction and were maintained on tacrolimus, mycophenolate mofetil (MMF), and a prednisone taper. A total of 143 LTx recipients were evaluated. Mean age in the older group was 65 ± 3.8 compared to 49 ± 10.4 years in the younger group (p < 0.0001). Mean tacrolimus levels and the duration of MMF and steroids were comparable. Both groups had a similar incidence of first rejection within 1 year (19.2% in the elderly group vs. 23.1% in the younger group, p = 0.57). There were no statistical difference in terms of infection, malignancy, or patient survival. In conclusion, our data suggests that elderly LTx recipients, when treated with a similar level of IS, had similar 1 year incidence of rejection, infection, malignancy, and patient survival as younger LTx recipients. •Elderly liver transplant recipients may benefit from reduced immunosuppression without increasing the risk of rejection.•This was a retrospective evaluation of clinical outcomes in Elderly liver transplant recipients compared to a younger group.•Maintained on a similar level of immunosuppression, both groups had a similar 1 year incidence of rejection.•There were no statistical difference in terms of infection, malignancy, or patient survival.•Elderly recipients may need to be maintained on a standard immunosuppression regimen during the first year of liver transplant.