Details

Autor(en) / Beteiligte

• Regauer, Sigrid
• Reich, Olaf

Titel

The origin of Human Papillomavirus (HPV) — induced cervical squamous cancer

Ist Teil von

• Current opinion in virology, 2021-12, Vol.51, p.111-118

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •The vulnerable area or epithelial site at risk for HPV-induced squamous cervical cancer is prenatally determined.•The area at risk for squamous cervical cancer is defined by the distribution of subcolumnar reserve cellsSquamous cancers arise primarily via squamous metaplasia from proliferating CK17/p63 reserve cells of urogenitalsinus origin.•The majority of squamous cancer arise in immature metaplastic epithelium in a linear fashion via thin HSIL and thick HSILOnly a minority of squamous cancer arise in thick glycogenated epithelium, the sofar preferred model for HPV-research. Most research models of HPV-associated squamous cervical carcinogenesis focus on stratified glycogenated squamous epithelium, a permissive environment for HPV-life-cycle completion, while immature squamous metaplastic epithelium and reserve cells as targets of HPV-infection have received less attention. Subcolumnar reserve cells of urogenital sinus origin with a CK17/p63-phenotype serve as the primary stem cell for squamous metaplasia. The area of manifest or potential squamous metaplasia, referred to as transformation zone, is the site where most squamous cancers occur after a transforming HPV infection of proliferating reserve cells and/or metaplastic epithelium. Improper use of terminology, in particular confusion of transformation zone with transition zone (synonymous: squamous-columnar junction or SCJ), as well as poorly substantiated postulates of a stem cell niche at the squamous-columnar junction with ‘embryonic stem cell markers’ have complicated understanding of HPV-related squamous carcinogenesis. Reserve cells as target cells and reservoirs of HPV should move into future research focus.