Details

Autor(en) / Beteiligte

• Van de Walle, Tim
• Cools, Lore
• Mangelinckx, Sven
• D'hooghe, Matthias

Titel

Recent contributions of quinolines to antimalarial and anticancer drug discovery research

Ist Teil von

• European journal of medicinal chemistry, 2021-12, Vol.226, p.113865-113865, Article 113865

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Quinoline, a privileged scaffold in medicinal chemistry, has always been associated with a multitude of biological activities. Especially in antimalarial and anticancer research, quinoline played (and still plays) a central role, giving rise to the development of an array of quinoline-containing pharmaceuticals in these therapeutic areas. However, both diseases still affect millions of people every year, pointing to the necessity of new therapies. Quinolines have a long-standing history as antimalarial agents, but established quinoline-containing antimalarial drugs are now facing widespread resistance of the Plasmodium parasite. Nevertheless, as evidenced by a massive number of recent literature contributions, they are still of great value for future developments in this field. On the other hand, the number of currently approved anticancer drugs containing a quinoline scaffold are limited, but a strong increase and interest in quinoline compounds as potential anticancer agents can be seen in the last few years. In this review, a literature overview of recent contributions made by quinoline-containing compounds as potent antimalarial or anticancer agents is provided, covering publications between 2018 and 2020. [Display omitted] •Quinolines are considered to be privileged structures in medicinal chemistry.•Quinoline-based antimalarials and anticancer agents have attracted considerable attention in recent years.•This review focuses on developments concerning antimalarial and anticancer quinolines in the period 2018–2020.