Details

Autor(en) / Beteiligte

• Laitano, Orlando
• Murray, Kevin O.
• Leon, Lisa R.

Titel

Response to Comment on “Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture”

Ist Teil von

• Sports medicine (Auckland), 2022-03, Vol.52 (3), p.673-675

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• 1Mechanistic Link Between Exertional Heat Stroke (EHS) and Malignant Hyperthermia (MH) It appears that van den Bersselaar et al. question the data and methods reported by Sagui et al. [...]we are unable to take responsibility for or provide specific answers to the concerns regarding study design as well as lack of confirmation by others. Rather, MH patients often display whole-body rigidity, suggesting that it is a more global phenomenon. [...]we respectfully disagree that the use of the biceps brachii represents a limitation in the Sagui et al. [1] argue that because exertional myalgia, elevated creatine kinase levels, and skeletal muscle weakness are part of the spectrum of RYRl-related disorders, a positive IVCT/CHCT test by patients who do not necessarily have MH may not be interpreted as false positive. [...]it is too simplistic to conclude that it is wrong and misleading to employ comparative physiology in a scientific effort to understand a complex manifestation such as EHS and MH. 5 Treatment of MH Our main goal in the review article [2] was to communicate that there is no evidence to support the use of dantrolene sodium (DS) as treatment for EHS victims.