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Response to Comment on “Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture”
Ist Teil von
Sports medicine (Auckland), 2022-03, Vol.52 (3), p.673-675
Ort / Verlag
Cham: Springer International Publishing
Erscheinungsjahr
2022
Quelle
MEDLINE
Beschreibungen/Notizen
1Mechanistic Link Between Exertional Heat Stroke (EHS) and Malignant Hyperthermia (MH) It appears that van den Bersselaar et al. question the data and methods reported by Sagui et al. [...]we are unable to take responsibility for or provide specific answers to the concerns regarding study design as well as lack of confirmation by others. Rather, MH patients often display whole-body rigidity, suggesting that it is a more global phenomenon. [...]we respectfully disagree that the use of the biceps brachii represents a limitation in the Sagui et al. [1] argue that because exertional myalgia, elevated creatine kinase levels, and skeletal muscle weakness are part of the spectrum of RYRl-related disorders, a positive IVCT/CHCT test by patients who do not necessarily have MH may not be interpreted as false positive. [...]it is too simplistic to conclude that it is wrong and misleading to employ comparative physiology in a scientific effort to understand a complex manifestation such as EHS and MH. 5 Treatment of MH Our main goal in the review article [2] was to communicate that there is no evidence to support the use of dantrolene sodium (DS) as treatment for EHS victims.