Details

Autor(en) / Beteiligte

• Melero, Ignacio
• Teijeira, Alvaro
• Aranda, Fernando
• Berraondo, Pedro

Titel

Firefighters for the Wrong Type of Inflammation in Tumors

Ist Teil von

• Cancer discovery, 2021-10, Vol.11 (10), p.2372-2374

Ort / Verlag

United States

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• In this issue of , Pelly and colleagues show that inhibition of prostaglandin E synthesis or its activity on EP2 and EP4 receptors synergizes with anti-PD-1 immunotherapy and triggers a potent intratumoral IFNγ response in mouse models and in fresh surgical human tumor explants. This therapeutic strategy is in line with other interventions that aim at fostering immunotherapy by means of quenching protumor inflammation. .