Details

Autor(en) / Beteiligte

• Yao, Qingqing
• Liu, Yu
• Pan, Yining
• Li, Yijia
• Xu, Liming
• Zhong, Yiming
• Wang, Wei
• Zuo, Jiayi
• Yu, Hao
• Lv, Ziru
• Chen, Hao
• Zhang, Lishu
• Wang, Bailiang
• Yao, Hongyan
• Meng, Yongchun

Titel

Long-term induction of endogenous BMPs growth factor from antibacterial dual network hydrogels for fast large bone defect repair

Ist Teil von

• Journal of colloid and interface science, 2022-02, Vol.607, p.1500-1515

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] Osteoinductive, osteoconductive, and antibacterial properties of bone repair materials play important roles in regulating the successful bone regeneration. In the present work, we developed pH-sensitive gelatin methacryloyl (GelMA)-oxidized sodium alginate (OSA) hydrogels for dual-release of gentamicin sulfate (GS) and phenamil (Phe) to enhance the antibacterial activity and to promote large bone defect repair. Controlled release of GS was achieved through physical blending with GelMA-OSA solution before photo-polymeriaztion, while Phe was encapsulated into mesoporous silicate nanoparticles (MSN) within the hydrogels. In vitro antibacterial studies against Staphylococcus aureus and Escherichia coli indicated the broad-spectrum antibacterial property. Moreover, in vitro cell tests verified the synergistically enhanced osteogenic differentiation ability. Furthermore, in vivo studies revealed that the hydrogels significantly increased new bone formation in a critical-sized mouse cranial bone defect model. In summary, the novel dual-network hydrogels with both antibacterial and osteoinductive properties showed promising potential applications in bone tissue engineering.