Details

Autor(en) / Beteiligte

• Coura, Bruna Pizziolo
• Santos, Jean Nunes
• Fonseca, Felipe Paiva
• Bernardes, Vanessa Fátima
• Aquino, Sibele Nascimento
• Jorge Júnior, Jacks
• Vargas, Pablo Agustin
• Romañach, Mário José
• Andrade, Bruno Augusto Benevenuto
• Gomez, Ricardo Santiago
• Gomes, Carolina Cavalieri

Titel

Adenoid ameloblastoma with dentinoid is molecularly different from ameloblastomas and adenomatoid odontogenic tumors

Ist Teil von

• Journal of oral pathology & medicine, 2021-11, Vol.50 (10), p.1067-1071

Ort / Verlag

Denmark: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Background Adenoid ameloblastoma is a rare epithelial neoplasm, histologically characterized by the presence of ameloblastoma‐like features, duct‐like structures, epithelial whorls, and cribriform architecture. Dentinoid material is usually present. Some advocate adenoid ameloblastoma is an ameloblastoma variant. However, there are overlapping features not only with ameloblastoma, but also with adenomatoid odontogenic tumor. Most ameloblastomas are characterized by the presence of BRAF p.V600E mutations and adenomatoid odontogenic tumors harbor signature KRAS mutations. The molecular features of adenoid ameloblastoma remain unknown. Methods Nine adenoid ameloblastoma cases were screened by TaqMan allele‐specific qPCR to assess BRAF p.V600E, ameloblastoma signature mutation, and KRAS p.G12V and p.G12R, adenomatoid odontogenic tumor signature mutations. Results BRAF and KRAS mutations were not detected in any of the adenoid ameloblastoma cases. Conclusion The molecular results support adenoid ameloblastoma as an entity distinct from adenomatoid odontogenic tumor and ameloblastoma.