Details

Autor(en) / Beteiligte

• Liu, Jing‐Yi
• Zhang, Jin‐Ming
• Zhan, Hao‐Su
• Sun, Li‐Ying
• Wei, Lin

Titel

EBV‐specific cytotoxic T lymphocytes for refractory EBV‐associated post‐transplant lymphoproliferative disorder in solid organ transplant recipients: a systematic review

Ist Teil von

• Transplant international, 2021-12, Vol.34 (12), p.2483-2493

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Summary The use of Epstein–Barr virus‐specific cytotoxic T lymphocytes (EBV‐CTLs) in adoptive immunotherapy in hematopoietic stem cell transplantation (HSCT) patients with post‐transplantation lymphoproliferative disorder (PTLD) has demonstrated safety and effectiveness. EBV‐CTLs might also be the effective treatment of refractory PTLD of solid organ transplantation (SOT) recipients. Two independent assessors searched Pubmed, Embase, Cochrane Library, and Web of Science from their inception to November 2020. Eleven studies with 76 patients (42, 55% male) were included. We extracted the data and completed the quality assessments. Most of the studies were from Europe and the USA. Liver and kidney transplantation accounted for most of the transplant types. Thirty‐five (46.1%) patients were diagnosed with monomorphic PTLD, and B lymphocyte type was the most common. All the patients received primary treatment for PTLD while it was ineffective. CTLs included autologous EBV‐CTLs (15/76, 22%) and HLA‐matched third‐party EBV‐CTLs (61/76, 78%). The response rate for EBV‐CTL treatment of refractory PTLD was 66%. Of 50 patients, 36 achieved complete remission and 14 achieved partial remission. EBV‐DNA level decreased in 39 patients. Adverse reactions were rare and mild. We conclude that adoptive therapy with EBV‐specific CTLs is safe, well‐tolerated, and effective in PTLD. In this systematic review we firstly reviewed the reported studies and discussed the use of EBV‐CTLs in the treatment of refractory PTLD of SOT recipients. We found that EBV‐CTL therapy was reliable and effective.