Details

Autor(en) / Beteiligte

• Gonzalez de Villambrosia, Sonia
• Bastos, Mariana
• Palanca, Javier Menarguez
• Cruz, Jorge Gayoso
• Navarro, José-Tomás
• Tapia, Gustavo
• Alonso, Sara Alvarez
• Martin, Alejandro
• Blanco, Oscar
• Abrisqueta, Pau
• Castellvi, Josep
• García-Noblejas, Ana
• Arranz, Reyes
• Adrados, Magdalena
• López, Andrés
• Montes-Moreno, Santiago

Titel

BCL2 translocation in high grade B cell lymphoma (NOS, DH/TH) is associated with reduced progression free survival

Ist Teil von

• Leukemia & lymphoma, 2022-01, Vol.63 (1), p.101-108

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• High Grade B Cell Lymphoma, NOS, and High Grade B Cell Lymphoma with Dual Hit or Triple Hit have been recently recategorized in the 2016 revision of the WHO classification of lymphoid neoplasms. In this study we have characterized the genetic, histopathological, and clinical features of a series of this type of lymphoid neoplasia (17 HGBCL NOS and 53 HGBCL DH/TH). HGBCL NOS showed better response to first line treatment than HGBCL with DH/TH but no significant differences in PFS or OS were found between the two categories. Survival analysis in the whole cohort of cases found that only the presence of BCL2 translocation was significantly associated with PFS. Other clinical features such as IPI, LDH or stage were equivalent in both categories. Furthermore, both high grade and DLBCL morphological patterns showed equivalent PFS and OS in this set of High grade BCL NOS/DH/TH. Key points BCL2 translocation in High Grade B Cell Lymphoma NOS and High Grade B Cell Lymphoma with DH/TH is associated with reduced progression free survival. Both high grade and DLBCL morphological patterns showed equivalent outcome regarding PFS and OS in HGBCL.