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Bubble lifetimes in DNA gene promoters and their mutations affecting transcription
Ist Teil von
The Journal of chemical physics, 2021-09, Vol.155 (9), p.095101-095101
Ort / Verlag
Melville: American Institute of Physics
Erscheinungsjahr
2021
Quelle
美国小型学会期刊集(AIP Scitation平台)
Beschreibungen/Notizen
Relative lifetimes of inherent double stranded DNA openings with lengths up to ten base pairs are presented for different gene promoters and corresponding mutants that either increase or decrease transcriptional activity in the framework of the Peyrard–Bishop–Dauxois model. Extensive microcanonical simulations are used with energies corresponding to physiological temperature. The bubble lifetime profiles along the DNA sequences demonstrate a significant reduction of the average lifetime at the mutation sites when the mutated promoter decreases transcription, while a corresponding enhancement of the bubble lifetime is observed in the case of mutations leading to increased transcription. The relative difference in bubble lifetimes between the mutated and wild type promoters at the position of mutation varies from 20% to more than 30% as the bubble length decreases.