Brain imaging and behavior, 2022-04, Vol.16 (2), p.659-670
2022
Details
- Autor(en) / Beteiligte
- Titel
- Spindle-related brain activation in patients with insomnia disorder: An EEG-fMRI study
- Ist Teil von
- Brain imaging and behavior, 2022-04, Vol.16 (2), p.659-670
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2022
- Link zum Volltext
- Quelle
- SpringerLink (Online service)
- Beschreibungen/Notizen
- Sleep spindles have been implicated in sleep protection, depression and anxiety. However, spindle-related brain imaging mechanism underpinning the deficient sleep protection and emotional regulation in insomnia disorder (ID) remains elusive. The aim of the current study is to investigate the relationship between spindle-related brain activations and sleep quality, symptoms of depression and anxiety in patients with ID. Participants ( n = 46, 28 females, 18–60 years) were recruited through advertisements including 16 with ID, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and 30 matched controls. Group differences in spindle-related brain activations were analyzed using multimodality data acquired with simultaneous electroencephalography and functional magnetic resonance imaging during sleep. Compared with controls, patients with ID showed significantly decreased bilateral spindle-related brain activations in the cingulate gyrus (familywise error corrected p ˂ 0.05, cluster size 4401 mm 3 ). Activations in the cingulate gyrus were negatively correlated with Pittsburgh Sleep Quality Index scores ( r = -0.404, p = 0.005) and Self-Rating Anxiety Scale scores ( r = -0.364, p = 0.013) , in the pooled sample. These findings underscore the key role of spindle-related brain activations in the cingulate gyrus in subjective sleep quality and emotional regulation in ID.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1931-7557eISSN: 1931-7565DOI: 10.1007/s11682-021-00544-2Titel-ID: cdi_proquest_miscellaneous_2571050170
- Format
- –
- Schlagworte
- Anxiety, Biomedical and Life Sciences, Biomedicine, Brain, Brain - diagnostic imaging, Brain mapping, Data acquisition, EEG, Electroencephalography, Emotional regulation, Emotions, Error correction, Female, Functional magnetic resonance imaging, Humans, Insomnia, Magnetic resonance imaging, Magnetic Resonance Imaging - methods, Male, Medical imaging, Mental depression, Mental disorders, Neuroimaging, Neuropsychology, Neuroradiology, Neurosciences, Original Research, Psychiatry, Signs and symptoms, Sleep, Sleep disorders, Sleep Initiation and Maintenance Disorders - diagnostic imaging, Spindles